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Together, these results support an atypical interaction between XPO-1 and NHR-49 that may facilitate translocation of NHR-49bound DNA to the nuclear pore

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The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations