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Similarly, other flavonoids such as 7,3,4-trihydroxyisoflavone, skullcapflavone II, and orobol have been reported to downregulate CCL17 and CCL22 expression both in mouse and HaCaT AD models

We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig

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