This requirement itself can affect side effects, as taking the tablet with food or too much water reduces absorption and can alter the side effect profile
Manage Stress: Stress makes your body produce more stomach acid
If normal, start 1000 mcg oral b12 daily as prevention given multiple risk factors (age, metformin, PPI, now semaglutide)
If you have a batch of prefilled syringes at your current dose, you cannot easily reduce them without wasting medication
You also arent delaying the emptying of your stomach to such an extreme that medications dont get where they need to go. That said, there are some medications that should be used cautiously while taking semaglutide, including other drugs that lower blood sugar like insulin
What to Expect as Your Body Adjusts The adjustment period with semaglutide typically lasts a few weeks to a couple of months