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Rodents have a higher density of thyroid C cells and greater glucagon-like peptide-1 receptor (GLP-1R) expression, leading to increased calcitonin secretion and C-cell hyperplasia
When combined with insulin or sulfonylureas, dose adjustments of these medications are frequently necessary to reduce the risk of hypoglycemia, as the glucose-lowering effects may be additive
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The slightly larger volumes at the 0.25 mg and 0.5 mg doses are easier to see and measure, especially for people new to self-injection