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Avoid it if you or your family have a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2)

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Lancet 382 , 14131423 (2013)

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p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]