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Traditionally, GLP-1 receptor agonists required injection, which limited acceptance among some patients

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Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity "...our approach demonstrates the feasibility of using peptide-mediated targeting to achieve cell-specific ionotropic receptor modulation..."Previous work had shown that injecting NMDA receptor antagonists into the lateral hypothalamus inhibits food intake and causes a reduction in body weight.But due to brain wide expression of NMDA receptors multiple neuronal circuits are affected, leading to a significant side effects...Which is why the authors fused an existing NMDA receptor antagonist with the now widely popular neuropeptide Glp1

Other interesting results on the role of protein intake in women suffering from endometriosis were reported in the study by Yamamoto et al