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Possible Direct Mechanisms Although indirect effects dominate, GLP-1 receptors are expressed in reproductive tissues, suggesting potential direct roles: Ovarian Effects: Animal studies demonstrate GLP-1 receptor activation can influence granulosa cell function, increase cyclic adenosine monophosphate (cAMP), and modulate steroidogenesis
Both activator protein 1 and nuclear factor (NF)-B mediate regulation of GSTP through a redox process (33)
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Neuroinflammation in murine cirrhosis is dependent on the gut Microbiome and is attenuated by fecal transplant
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