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IRE1 activation leads to the splicing of XBP1, which upregulates genes involved in protein folding and ERAD

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We dont fully understand to what extent their neurological effects are a direct consequence of targeting brain-specific pathways or merely a downstream benefit of improved metabolic health

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First, rigorously designed randomized controlled trials in human populations are needed to systematically evaluate the protective role of L-citrulline in male spermatogenesis and to explore its potential synergistic applications in assisted reproductive technologies