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357 However, prophylactic depletion of Tregs via intraperitoneal diphtheria toxin injection was shown to stabilize the intestinal immune barrier and reduce bacterial translocation to the inflamed pancreas but paradoxically intensified the proinflammatory response in experimental AP models

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Type 2 diabetes studies: Investigated for long-term glycemic control and clinical outcomes as a GLP-1-based antidiabetic therapy (e.g., Victoza)

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Mental preparation involves setting realistic expectations, understanding that sustainable weight loss typically occurs at 1-2 pounds per week, and recognizing that lifestyle changes require ongoing commitment beyond medication treatment