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Pre-existing gastrointestinal conditions, particularly gastroparesis or irritable bowel syndrome, significantly affect tolerability and may necessitate slower escalation or lower maintenance doses

This evolutionary defense mechanism has profound implications for human health

What they found: Darkening of existing nevi in 85 % of patients New nevi in 30 % Atypical features on dermatoscopy in 40 % Two cases of malignant melanoma in the followed cohort No evidence of a causal relationship, but associative correlation Why it matters: These are the most serious published safety data for Melanotan II

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