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However, the risk of bone fractures may be increased by supplements containing 25 mcg or more daily, according to some research

The article also notes that a change in how well the medication seems to work has several possible explanations

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However, it doesnt absorb well, and requires a methyl donor (a natural antidote and an antagonist for toxins) to detoxify it before it can convert to one of the useful forms of B12

Inositol helps regulate insulin sensitivity and neurotransmitter activity, indirectly affecting fat distribution and mood