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it introduces an uncontrolled variable into any protocol relying on precise dosing calculations

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But the data has gaps and limits

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Toft G, Hagmar L, Giwercman A, Bonde JP: Epidemiological evidence on reproductive effects of persistent organochlorines in humans

However, if a gland is no longer functioning due to surgical removal or advanced ovarian failure, peptides alone may not be sufficient, and direct hormone replacement may still be necessary