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In the same animal model, it an increase of serum TAG, total lipid, LDL cholesterol, total cholesterol, CRP, globulin, urea, creatinine, and NOx levels has been observed, with a decrease in serum total protein, HDL-cholesterol, albumin: globulin ratio and total anti-oxidants in the arthritis animals, all indicating hypoalbuminemia and globulinemia, dyslipidemia, oxidative stress, inflammation, and impairment of kidney functions (171)

12.5 Patients on Polypharmacy Regimens Polypharmacy increases the risk of pharmacokinetic and pharmacodynamic interactions