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Healthy older men with normal body weight usually do not experience a significant drop in testosterone levels in their blood, and there is no such thing as male menopause or andropause

Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

Accessed October 18, 2025

Phase I makes the toxin reactive (adds a handle)

Targeting metabolic vulnerabilities in specific macrophage subsets, such as limiting ferroportin-mediated iron export in M2 TAMs or enhancing ACSL4-dependent lipid peroxidation in inflammatory TAMs, may shift the TME toward a ferroptosis-permissive state