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Biosynthesis of the protein encoded by the c-met proto-oncogene
Alternate the injection sites, especially with subcutaneous injections, to avoid irritation
Abdel-Khalek AE, El-Ratel IT, Wafa WM, El-Nagar HA, Younan GE, Fouda SF
Alterations in FOXO pathways have been associated in laboratory models with glucose dysregulation, lipid imbalance, and in some cases, enhanced susceptibility to metabolic disorders
Dosing typically begins at a lower dose, suggested initiation of 20 units (0.2 mL) weekly for the first 4 weeks, then escalates according to a titration schedule: Weeks 14: Inject 20 units (0.2 mL) one time per week Weeks 58: Inject 40 units (0.4 mL) one time per week Weeks 912: Inject 70 units (0.7 mL) one time per week Weeks 1316: Inject 90 units (0.9 mL) one time per week Weeks 1720: Inject 120 units (1.2 mL) one time per week Week 21+: Inject 140 units (1.4 mL) one time per week Dosing may deviate from this pattern to accommodate patient-specific needs
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