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Houghton LA, Lea R, Agrawal A, Reilly B, Whorwell PJ

The medication's long half-life means some therapeutic effect persists for several days

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According to the SmPC, these include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Decreased appetite (common, affecting up to 1 in 10 people) Vomiting (common) Abdominal pain (common) Abdominal distension (common) Constipation (common) Dyspepsia (common) Flatulence (common) These gastrointestinal effects typically occur during the initial weeks of treatment and often diminish as the body adjusts to the medication