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10.3389/fmicb.2023.1330029 62 LosurdoG.CubisinoR.BaroneM.PrincipiM.LeandroG.IerardiE.et al (2018)

However, this response was not observed in M1 macrophages, which were able to sustain cell survival and their antimicrobial functions

DET1 H485 and R11 form salt bridges with COP1 E492 and E511, respectively

As mentioned, the Sec 46 residue in GPX4 showed to be essential for the enzymatic activity [35]

Additionally, risk assessment of drug interactions faces challenges, including pharmacokinetic interactions, cytotoxicity, and interindividual variability (Zhang et al., 2025)