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A Caco-2 bidirectional transport assay showed an apparent permeability (P app ) of 34.2 10 6 cm/s from apical to basolateral and 45.2 10 6 cm/s from basolateral to apical, with an efflux ratio of 1.33, indicating high permeability and no significant efflux

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PMID 1299794

Materials and methods: Islets and nanofat were isolated from wild type donor mice

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The concept is particularly valuable in the interpretation of measurements of drug concentrations in plasma, which can be used to monitor adherence to treatment and to assess likely response (Table 53.2)