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doi: 10.1016/S0140-6736(18)30726-8 314 PetitJMCercueilJPLoffroyRDenimalDBouilletBFourmontCet al

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Dysregulation of these processes due to VHL mutations contributes to the pathogenesis of Von Hippel-Lindau disease, a hereditary cancer syndrome characterized by the development of tumors and cysts in multiple organs, including the brain, spine, retina, and kidneys, particularly clear cell renal cell carcinoma (ccRCC)