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Circulation 143 (21), e984e1010

18 In the context of IIH pathophysiology, the use of GLP-1 RAs extends beyond the weight-modifying effects (figure)

Are you afraid of falling when you stand up or try to walk

Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]

Commercial insurance and Medicare in New York Roughly one in five large-employer plans covered GLP-1s for weight loss in 2025, with the trend upward heading into 2026

Here's how our clinical team thinks about it, and what we actually recommend