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Semaglutide works by activating GLP-1 receptors, which helps decrease appetite and overall calorie intake, making it highly effective for weight loss and glycemic control when used consistently

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For patients who have been doing well on semaglutide but havent hit their goals, this is now a meaningful escalation option before switching drug classes entirely

Weight loss from weekly semaglutide injections accompanied significant reductions in pain related to knee osteoarthritis, according to data published in The New England Journal of Medicine

Some medical issues make losing weight especially difficult, and semaglutide can help break through those barriers

Clinical studies A total of 22 completed clinical studies were identified (Table 1 and Extended Data Tables 1 and 2), with another 8 clinical trials still ongoing (Supplementary Section 3)