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The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks

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Mobilization of lysosomal-related vesicles into the axon is dependent on proper coupling of the adapter system that includes the BORC complex, the small GTPase Arl8b, and the adapter protein SKIP, which mediates coupling of lysosomes to kinesin-1 [51]