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Weight reduction via tirzepatide improves liver histology by reducing hepatic steatosis through sustained caloric deficit and improved insulin sensitivity the SURMOUNT trials showed significant reductions in ALT and AST alongside body weight loss
Stage III (72-96 hours) = Maximal stage of hepatotoxicity = Hepatic failure Clinical features Recurrence of systemic symptoms (anorexia, nausea, vomiting, malaise) Emerging signs & symptoms of hepatic failure : Encephalopathy, jaundice, coagulopathy, hypoglycemia, lactic acidosis, shock
What are potential side effects
These encompass rolling scars, boxcar scars, ice pick scars, macular erythematous scars, and keloids
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