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Additional concerns include the potential for rapid weight loss to affect nutritional status during the critical periconceptional period

DMF/MMF actions may also be indirect, including blocking of cytokine-activated I-B, a cytoplasmic complex that can induce degradation of a NF-B inhibitor, releasing inflammatory transcription factors to the nucleus to induce inflammation

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But beyond the headlines and celebrity testimonials, theres a fundamental question: What happens after the weight comes off