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Front Oncol 12:953055

Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers

In March 2026, Aardvark Therapeutics announced that the US FDA had placed a full clinical hold on its investigational new drug application for ARD-101 related to the Companys previously announced voluntary pause

The non-hormonal mechanism makes them safe to use alongside hormone therapy if desired

and other applicable government regulations