In that time, Ive watched the clinical culture around GLP-1s split in two directions
True tachyphylaxis with GLP-1 receptor agonists remains controversial in the clinical literature
These experiments leave us with the knowledge that activation of these neurons has the capacity to significantly reduce food intake and influence the function of the cardiovascular system, but currently, we have a very limited idea under which physiological conditions this occurs
Patients should be counseled that close follow-up is recommended and that there can be temporary worsening of diabetic retinopathy and diabetic macular edema with rapid intensive glycemic control
Although the etiology of depression has not been fully elucidated, current scientific data emphasize the role of neurotrophic factors deficiencies, disturbed homeostasis between the nervous system and the immune and endocrine systems, as well as disturbances in brain energy metabolism and dysfunctions in the gut-brain axis as important factors in the pathogenesis of this neuropsychiatric disorder
At this time, there is no clinical evidence showing that over-the-counter GLP-1 patches produce the same appetite or weight loss effects as prescription GLP-1 medications