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The PHD finger of ING4 and ING5 binds to methylated H3K4 (Champagne et al, 2008

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While the emphysema state results in loss of alveolar spaces and low sputum production, the bronchitis phenotype results in narrowing of the airways as well as blocking of the alveolar spaces with mucus obstruction leading to chronic cough, sputum production, and exacerbations (Szalontai et al., 2021

Methionine is an important source of sulfur for numerous compounds in the body, including cysteine and taurine