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Interestingly, treatment with estradiol (OVX+E2) resulted in reduced body weight in compared to OVX animals, though the OVX + E2 group of animal has higher body weight than the intact females
However, most of this evidence comes from case reports and small observational cohorts, with a conspicuous lack of large-scale prospective trials
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(2013) [53], treatment with low doses of NAC and the use of FEV 1 as a parameter for the evaluation of COPD in some studies may be responsible for the lack of effectiveness of the antioxidant and anti-inflammatory treatment of NAC in these patients
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