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350,351 Loss-of-function mutations in Parkin (PARK2), an E3 ubiquitin ligase, underlie autosomal recessive Parkinsons disease

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Many neuronal processes regulated by Ca 2+ are mediated through calmodulin, a ubiquitous Ca 2+ -sensing protein that binds and modifies the function of a diverse range of downstream effectors in response to increased intracellular Ca 2+ [30]