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218,219 Indeed, the loss of dopaminergic neurons is considered the hallmark of Parkinsons disease, and restoration of dopaminergic signaling is the focus of most treatments

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doi: 10.1001/jamainternmed.2024.2525 [DOI] [PMC free article] [PubMed] [Google Scholar] 13.Hall KD

Our team has analyzed the available data to create a practical framework for researchers

The structure-activity relationship (SAR) studies conducted by Chugai and subsequently by Eli Lilly explored modifications across the molecule's three principal domains: the tetrahydropyran ring system, the indazole heterocycle, and the substituted phenyl ring