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ECG monitoring may be necessary, particularly if there are cardiac risk factors or if these medications are used with other QT-prolonging drugs (including ondansetron)

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These pathways include sulfation, glucoronidation, glutathione conjugation, acetylation, amino acid conjugation and methylation

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The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels