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In the SURMOUNT-5 trial, participants treated with Zepbound achieved an average weight reduction of 20.2% compared to 13.7% with Wegovy at 72 weeks

This is due primarily to its twofold increase in fibroblast proliferation and vascular tissue growth

Semaglutide and tirzepatide do not activate it

Primary bone marrowderived macrophages (BMMs) cells were extracted from the whole bone marrow of the tibia and femur bone in male 6-week-old C57BL/6 mice (GemPharmatech, Nanjing, China)

The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-alpha Expression in Macrophages

The prescription requirement reflects the medication's potency and the importance of professional oversight