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Following treatment with MnIIITDE-2-ImP5+, a catalytic antioxidant with the ability to scavenge ROS, significant reductions in TNF- and IL-1 levels were reported in the hippocampusin addition to IL-6 and KC/GRO in the piriform cortexcompared to pilocarpine-only treated rats [53], thus demonstrating directly that ROS can modulate pro-inflammatory cytokine production post-seizure

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