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Wegovy is a peptide that is degraded by proteolytic enzymes and does not undergo hepatic metabolism via cytochrome P450 enzymes, whilst bismuth subsalicylate acts locally in the gastrointestinal tract with some systemic absorption of salicylate

There are practical, evidence-based strategies you can use to combat nausea while benefiting from GLP-1 medications

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Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy

10.1038/s41583-019-0132-6 170