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The Phase 3 program includes trials in obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH, formerly known as NASH)

GIP receptors sit on fat cells and in the liver, providing additional metabolic signaling: Enhanced adipocyte metabolism fat cells respond better to signals telling them to release or burn fat Improved nutrient partitioning dietary fat gets directed toward oxidation rather than storage Greater weight loss tirzepatide produces about 50% more weight loss than semaglutide at comparable doses This translates to stronger lipid effects: about 20-30% triglyceride reduction in major obesity trials, and a large liver-fat signal in MRI studies

There are no familiar pills or even injections like the sort involved with some of the more intense allergy treatments

[Updated 2024 Jan 11]

Clinical trial data from pre-marketing studies did not identify significant increases in psychiatric adverse events compared to placebo

The SURPASS and SURMOUNT clinical trial programs studied tirzepatide across multiple doses and populations