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Drugs like semaglutide (Wegovy) and tirzepatide (Zepbound) have shown to improve efficacy compared to older weight-loss medications, with patients losing up to 20% of their body weight

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[11] Furthermore, a meta-analysis conducted by Zhu et al [12] found a strong correlation between the prevalence of myocardial infarction (MI) and obesity, as well as the importance of maintaining weight as a preventative measure

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In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]

Accessed January 10, 2025