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Excessive Caffeine Moderate coffee intake is generally fine, but overconsumption of caffeine raises cortisol levels and contributes to oxidative stress

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Oxidative stress / antioxidant-pathway investigations

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The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]

Wound Repair and Regeneration, 2015, 23(1): 1-13