It can also increase the risk of pancreatitis
6.6 Effects on renal functions The result of clinical trials of tirzepatide on kidney function indicates potential renal advantages, especially in individuals with type-2 diabetes (T2D) and a heightened cardiovascular risk.In the SURPASS-4 (NCT03730662) trial, tirzepatide was observed to reduce occurrence of the composite kidney endpoint (like eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new-onset macro albuminuria) in comparison to those receiving insulin glargine
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While mathematical modelling suggests dosing every other week might retain 75% of effectiveness, patient reports indicate noticeable increases in hunger and appetite during off weeks
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This article walks through what the clinical evidence actually shows including data from the major trials and what you can do about it
