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Grouping: Control group (physiological saline intra-articular injection), AOD 9604 group (0.25mg/joint), hyaluronic acid (HA) group (0.5mg/joint), AOD 9604+HA combination group

The 2025 Zdrada-Nowak review in International Journal of Molecular Sciences confirmed the clinical evidence for AH-8 in wrinkle reduction, elasticity, and hydration, but flagged the specific limitation that low intrinsic skin penetration is the main efficacy ceiling for topical use [12]

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When this happens, the body treats those contents as a foreign substance and mounts an immune response

(Funded by) Hunan Provincial Natural Science Foundation Project (2023JJ30452)

The percentage is a choice reasonable formulators could debate at the margins 0.10% versus some other figure in the studied range