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7F), demonstrating marked SV depletion in presynaptic terminals with complete absence in localized areas, synaptic membrane disorganization manifested by blurred and thickened synaptic clefts with indistinct pre-/postsynaptic boundaries, and abnormal PSD thickening with reduced electron density

Pharmacogenomics Genetic polymorphisms in the drug metabolizing enzymes may be an important factor in the differential therapeutic and toxic responses in humans

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Additionally, intestinal metabolites of CGA and microbiota alterations contribute to these effects by enhancing the antioxidant system and reducing endotoxemia

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