However, limitations include variability in bioavailability, the need for precise dosing, and limited long-term clinical trial data
Thats a big deal because it suggests semaglutide may be boosting heart health directly, perhaps in addition to the typical benefits that accompany weight loss, says Caroline Apovian, an obesity medicine specialist at Harvard Medical School and Brigham and Womens Hospital in Boston
If you experience prolonged or significant side effects, you might benefit from a slower dose escalation scheme or a lower maintenance dose

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Saxenda (liraglutide) is approved in Canada for chronic weight management with diet and physical activity, for adults with obesity (BMI 30 or higher) or overweight (BMI 27 or higher) plus at least one weight-related condition
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