Another prospective, observational study analysed the changes in health-related quality of life and emotional well-being in patients who had commenced GLP-1 analogue therapy (exenatide) in comparison with new insulin starters
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5.3 GLP-1s anti-inflammatory effects GLP-1 receptor agonists significantly reduce inflammation by modulating immune cell activity and suppressing the release of pro-inflammatory cytokines, such as TNF- , IL-6, and IL-1 (99101)
Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload
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