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Ann Neurol 1995;38(1):5157

Clinical evidence shows GLP-1 agonists produce significantly greater weight loss1522% of body weight in clinical trialscompared to phentermine's typical 510% weight reduction

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Clinical trials demonstrate that these medications deliver impressive results: They help people with type 2 diabetes achieve A1C reductions of 1.5-2.0% Most people lose 10-15% of their body weight (thats 20-30 pounds for someone weighing 200 pounds) Cardiovascular outcomes improve significantly Insulin sensitivity increases by 25-40% However, success brings new questions