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(One exception to this is vitamin B12

Only the agency makes such determinations, but some of the health claims combined with the nature of these peptides raise the question: could they cross the line from supplements into biological drug territory

Reviews of realworld data show that a significant portion of patients discontinue GLP1 therapy over time due to side effects, cost, or the burden of injections, which has driven interest in more convenient, needlefree delivery systems

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Nausea is the side effect patients ask about most, and it is the main reason the dose is raised gradually rather than started high

This appears to be largely mediated through improvements in insulin sensitivity and weight loss, which reduce androgen excess and normalise hypothalamic-pituitary signalling