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In the U.S., off-label prescribing is legal and relatively common

At the federal level, the Trump administration decided not to proceed with a Biden administration proposal to allow Medicare and require Medicaid to cover obesity drugs but recently launched their own obesity drug coverage initiatives to reduce costs and increase access (see Box 1)

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December 2025 A federal court has created a new multidistrict litigation, MDL No

While studies have shown increased c-Fos activity throughout the brain following administration of GLP-1 receptor agonists, further investigation revealed that this activation often does not correlate with the presence of GLP-1 receptors in those same neurons

The activation of MC4R leads to reduced food intake and increased satiety