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In vitro models to study confinement-induced responses include micropatterned lines [151], 2D micropatterned substrates [85], uni-axial compression [152], polydimethylsiloxane [153,154,155,156]- or polyacrylamide [90]-based microchannel devices, microniches [157, 158], and natural hydrogels [148, 159]

Cagrilintide Dosing Direct answer: cagrilintide is dosed once weekly and titrated upward over roughly 1620 weeks, with 2.4 mg being the highest dose studied (the dose used in the CagriSema program)

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