There is zero upside and massive downside
Cardiovascular and Kidney Protection: Optimizing 'Energy Allocation Priority' Patients with cardiovascular disease and chronic kidney disease (CKD) often experience energy metabolism disorders, manifested as insufficient energy supply to myocardial and renal tissues, increased oxidative stress, and intensified inflammatory reactions
Incretin-based therapies for the treatment of obesity-related diseases
We suspect that metabolic/bioenergetic reprograming, observed in this study, could also mediate short-term maintenance of -cell function upon withdrawal of GLP-1 analogues, as documented in humans and rodents by others 21, 33
The gut responds to higher drug concentrations by speeding things along
You can't really have one without the other, which is why managing them well in the early weeks matters so much