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MT-II has a cyclic truncated form and acts primarily upon melanocortin receptor 1 (MC1R) and melanocortin receptor 4 (MC4R) , respectively involved in melanogenesis and the regulation of sexual behavior

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Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches

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