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Researchers have shown that encapsulation increases plasma levels and enhances biodistribution to tissues involved in oxidative stress and aging, including the liver, skin, and mitochondria

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Pro-inflammatory macrophages (M1) have a higher succinate dehydrogenase in the TCA cycle which results in an increase of succinate which stabilize Hypoxia Inducible Factor 1 (HIF1) and in turns, promotes and sustain glycolysis activity [70]