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Today, we know that these are nutrient-responsive enteroendocrine cells that secrete a variety of peptide hormones, primarily derived from the proglucagon gene ( GCG ) (42)
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GRP75, chaperone Glucose-Regulated Protein 75
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The underlying mechanisms for increased HR remain to be fully elucidated, but may be related to a direct GLP-1 receptor effect on myocytes in the sinoatrial node of the human heart and/or stimulation of the sympathetic nervous system
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